Protein Details: Potassium channel subfamily K member 3
Protein ID
ICDB_Pro_0227
Protein Name
Potassium channel subfamily K member 3
Gene Name
Kcnk3; Task; Task1
Organism
Rattus norvegicus (Rat)
Length
411 amino acids
AlphaFoldDB
AF-O54912-F1-model_v4.pdb
Function
pH-dependent; voltage-insensitive; background potassium channel protein. Rectification direction results from potassium ion concentration on either side of the membrane. Acts as an outward rectifier when external potassium concentration is low. When external potassium concentration is high; current is inward.
Sequence
MKRQNVRTLALIVCTFTYLLVGAAVFDALESEPEMIERQRLELRQLELRARYNLSEGGYEELERVVLRLKPHKAGVQWRFAGSFYFAITVITTIGYGHAAPSTDGGKVFCMFYALLGIPLTLVMFQSLGERINTFVRYLLHRAKRGLGMRHAEVSMANMVLIGFVSCISTLCIGAAAFSYYERWTFFQAYYYCFITLTTIGFGDYVALQKDQALQTQPQYVAFSFVYILTGLTVIGAFLNLVVLRFMTMNAEDEKRDAEHRALLTHNGQAGGLGGLSCLSGSLGDGVRPRDPVTCAAAAGGMGVGVGVGGSGFRNVYAEMLHFQSMCSCLWYKSREKLQYSIPMIIPRDLSTSDTCVEHSHSSPGGGGRYSDTPSHPCLCSGTQRSAISSVSTGLHSLATFRGLMKRRSSV
PDB Structures
Ligand Binding
Binding Site
Disease
Location
Strongest expression in heart. Moderate expression in lung and brain. Low levels in liver; kidney and skeletal muscle. Low levels in liver; kidney and skeletal muscle. Low levels in liver; kidney and skeletal muscle.
DOI ID
10.1523/jneurosci.18-03-00868.1998
RefSeq
NP_203694.1